MEDICAL WOMEN'S HEALTH

The focus of this department is clinical and translational research specific to health issues important for the care of women. Currently, the department is working in conjuction with the Biomedical Laboratories for Integrative Cancer Research (BLICaR) at the College of Staten Island, City University of New York to develop new methods to improve cervical cancer screening.  A novel staining method for the diagnosis of cervical cancer and pre-cancerous lesions has been developed and has led to the filing of a patent with Staten Island University Hospital as the sponsoring institution. 

Division Director
Mario Castellanos, MD - Director of Clinical Research

• Recent Grants:  
  • Empire Clinical Research Investigator Program 
    2009-2011  
    New York State Department of Health   
    "Abnormal Pap Smear Management" 
    PI: M. Castellanos, MD
    Award: $150,000

  • Empire Clinical Research Investigator Program 
    2008- 2009 
    New York State Department of Health 
    "Effects of pre-admission glucose control reflected by HgA1C levels on the morbidity and mortality of patients admitted to the ICU."   
    PI: M. Castellanos, MD
    Award: $75,000

• International Patent Filing:

  • Title: A histochemical method to identify and predict disease progression of Human Papilloma Virus-infected lesions 
    Inventor: Mario Castellanos, MD 
    Application Assignment: SIUH and the Feinstein Institute for Medical Research International application No:PCT/US 09/49539 (WO/2010/003072) 
    Filing date: July 2, 2009 
    Publication: World Intellectual Property Organization:  http://www.wipo.int/pctdb/en/

• Invited Presentations:

  • LEEP versus cryotherapy: rates of HPV detection after treatment for CIN II/III. - American Society of Colposcopy and Cervical Pathology 2012 Biennial Scientific Meeting. March 2012, San Francisco, CA.

  • Endonuclease resistant DNA: A new marker to identify and predict disease progression of Human Papilloma Virus-infected lesions. - 26th International Papillomavirus Conference and Workshops. July 2010, Montréal, Canada.

  • Virion associated DNA: A novel histochemical marker to identify women that are at risk to develop precancerous lesions of the cervix. - Society of Gynecologic Oncology 41 ^st  Annual Meeting. March 2010, San Francisco, CA.

  • Endonuclease Resistant DNA: A novel histochemical biomarker to distinguish low from high grade cervical intraepithelial neoplasia. - American Society of Colposcopy and Cervical Pathologists.  March 2010, Las Vegas,  NV. 

• Publications:
  • Rajupet SR, Davidov A, Fidman B, Banerjee P, Maiman M, Castellanos MR. Clinical cornerstone: selecting the bivalent or quadrivalent prophylactic human papillomavirus vaccine. Mayo Clinic Proceedings. Manuscript ID 2012-0226 (submitted 2012).

     

  • Davidov A, Rajupet SR, Maiman M, Ahern K, Castellanos MR. LEEP versus cryotherapy: rates of HPV detection after treatment for CIN II/III . J Low Genit Tract Dis.[Abstract] Supplement April 2012, p S7.

    Castellanos MR, Davidov A, Punia V, Szerszen A, Maiman M, Lazzaro B, Ahern K, Banerjee P.  Endonuclease-resistant DNA: a novel histochemical marker for cervical intrapepithelial neoplasia and cervical carcinoma. Int J Gynecol Pathol. 2012 Jan;31(1):1-7.

  • Geara A, Castellanos MR, El-Imad B, Schuller-Levis G, Park E, Goldman M, Smith M, El-Sayegh S.  Effects of Parathyroid Hormone on Immune Function . Clin Dev Immunol. 2010;2010. pii: 418695.

  • Castellanos MR, Euisun Jung E, Park S, Schuller-Levis G, Odaimi M, Elsayegh S, Kleiner M, Elsoueidi R, Shtaynberg N, Park E. Effect of parathyroid hormone and teriparatide on immune function of human adherent and non-adherent leukocytes. Clin Neph 2010; 74(2):83-90.

  • Castellanos MR , Rothman J, Kleiner M. Tight glycemic control in critically ill patients . JAMA. 2010 May 5;303(17):1694.

  • Castellanos MR , Szerszen A, Saifan C, Zielboym I, Khoueiry G, AbiRafeh N, Wetz R, Kleiner M, Aoun N, Weiserbs K, Maniatis T, Rothman J. Fasting hyperglycemia upon hospital admission is associated with higher pneumonia complication rates among the elderly. Intern Arch Med 2010,3:16.

  • Zgheib M, Bushbinder S, Abi Rafeh N, Elya M, Raia C, Ahern K, Smith M, Costantino T, Flory M, Lafferty J, Castellanos MR. In Women Undergoing Cardiac Catheterization, Breast Arterial Calcifications on Mammgraphy do not Predict Coronary Artery Disease. Radiology 2010 Feb;254(2):367-73.

  • Morasse L, Davidov A, Castellanos MR. The role of human papillomavirus testing in cervical cancer screening. JAPPA 2009 Nov; 22:20-23.

  • Szerszen A, Seminara DP, Castellanos MR. Glucose control in the hospitalized elderly--a concern not just for patients with diabetes. Geriatrics. 2009 June;64(6):18-20.

  • Castellanos MR , Conte J, Abi Fadel D, Raia C, Forte F, Ahern K, Smith M, ElSayeh D, Buchbinder S. Improving Access and Outcomes in Breast Cancer with an Interdisciplinary Model of Care. The Breast Journal 2008 July-Aug;14(4):353-356.

  • Castellanos MR , Paramanathan K, Elsayegh S, Forte F, Buchbinder S, Kleiner M. Breast cancer screening in women with end-stage renal disease: the unrecognized effects of metastatic soft tissue calcification. Nat Clin Pract Neph 2008; 4(6):337-341.

  • Castellanos MR, Abi Fadel D, Seminara D. Glucose control in nondiabetic elderly pneumonia patients may be an overlooked therapeutic target. Clin Geriatrics 2008 May; 16(5):25-26.

  • Szerszen A, Seminara D, Castellanos MR. Is the aging population facing an impending crisis in access to breast health services?. J Am Ger Soc 2008;56(1)174-175.